Adverse drug reactions (ADRs) can be reported by a number of health care professionals including physicians, pharmacists and nurses, as well as patients. Common street drugs include: SynthCoke: The second generation, synthetic replacement for cocaine. Nonsteroidal anti-inflammatory drugs (NSAIDs) are members of a drug class that reduces pain, decreases fever, prevents blood clots, and in higher doses, decreases inflammation.Side effects depend on the specific drug but largely include an increased risk of gastrointestinal ulcers and bleeds, heart attack, and kidney disease. The Medication Appropriateness Tool for Comorbid Health Conditions in Dementia[11] (MATCH-D) warns that people with dementia are more likely to experience adverse effects, and that they are less likely to be able to reliably report symptoms.[12]. Cytostatics inhibit cell division. Other nonsurgical physical procedures, such as high-intensity radiation therapy, may cause burns and alterations in the skin. Most are mild, such as a stomach aches or drowsiness, and go away after you stop taking the drug. Where risks or harms is the reason for withdrawal, this will usually have been prompted by unexpected adverse effects that were not detected during Phase III clinical trials, i.e. Though it eases allergy symptoms, it also suppresses the activity of the body chemical acetylcholine , and that leads to drowsiness and a host of other side effects, including dry mouth . A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Nearly any drug can cause … [citation needed]. Some antibiotics may also damage the mitochondrion, a bacteria-derived organelle found in eukaryotic, including human, cells. Muromonab-CD3 is a murine anti-CD3 monoclonal antibody of the IgG2a type that was previously used to prevent T-cell activation and proliferation by binding the T-cell receptor complex present on all differentiated T cells. They can be reversible or irreversible, and a compromise must be found by the physician and the patient between the beneficial or life-saving consequences of surgery versus its adverse effects. Abacavir, sold under the brand name Ziagen, is a medication used to prevent and treat HIV/AIDS. Common side effects include heartburn and a rash. In the United States several reporting systems have been built, such as the Vaccine Adverse Event Reporting System (VAERS), the Manufacturer and User Facility Device Experience Database (MAUDE) and the Special Nutritionals Adverse Event Monitoring System. The IL-2a (CD25, T-cell activation antigen, TAC) is expressed only by the already-activated T lymphocytes. These studies are used to define the dosage to be used in human testing (phase I), as well as to calculate the maximum admissible daily intake. Urticaria (hives) can also be present. Serum sickness arises seven to fourteen days after the therapy has begun. It doesn't matter whether we're talking about aspirin or the most sophisticated pharmaceutical on the market, all drugs come with side effects.Many are minor, some are just an inconvenience, a few are serious, and some are just plain strange.. Perhaps the most common set of side effects for drugs taken internally involves the gastrointestinal system. Mycophenolic acid acts as a non-competitive, selective, and reversible inhibitor of Inosine-5′-monophosphate dehydrogenase (IMPDH), which is a key enzyme in the de novo guanosine nucleotide synthesis. The alkylating agents used in immunotherapy are nitrogen mustards (cyclophosphamide), nitrosoureas, platinum compounds, and others. lack of demand and relatively high production costs). Gastrointestinal effects (such as abdominal pain, constipation, diarrhea, flatulence, nausea, or vomiting) Light-headedness; Magnesium or vitamin B12 deficiency (usually only with long-term administration) Rash; Tongue discoloration or taste disturbances. This lowers the number of available T-cells, perhaps by sensitizing them for the uptake by the epithelial reticular cells. Each packet of Zegerid powder for oral suspension contains 460 mg of sodium and each capsule contains 304 mg of sodium. A psychoactive drug affects the brain.Most laws against drugs are against psychoactive drugs. They may also lead to non-compliance with a treatment regimen. Feeling irritable. Lawsuits over the rare side effects resulted in large jury awards and drew widespread attention. Excessive use of stimulants can promote stimulant psychosis. Like tacrolimus, ciclosporin (Novartis' Sandimmune) is a calcineurin inhibitor (CNI). It has been in use since 1983 and is one of the most widely used immunosuppressive drugs. Antibodies are sometimes used as a quick and potent immunosuppressive therapy to prevent the acute rejection reactions as well as a targeted treatment of lymphoproliferative or autoimmune disorders (e.g., anti-CD20 monoclonals). Drug Abuse Effects on Lifestyle. Adverse effects can occur as a collateral or side effect of many interventions, but they are particularly important in pharmacology, due to its wider, and sometimes uncontrollable, use by way of self-medication. For example, allergic reactions to radiocontrast materials often occur, and a colonoscopy may cause the perforation of the intestinal wall. In Australia, adverse effect reporting is administered by the Adverse Drug Reactions Advisory Committee (ADRAC), a subcommittee of the Australian Drug Evaluation Committee (ADEC). Browse our Drugs database to find information about prescription and over-the-counter drugs. These include: Methotrexate is a folic acid analogue. Immunosuppressive drugs can be classified into five groups: In pharmacologic (supraphysiologic) doses, glucocorticoids, such as prednisone, dexamethasone, and hydrocortisone are used to suppress various allergic, inflammatory, and autoimmune disorders. Nevertheless, they do not prevent an infection and also inhibit later reparative processes. [2], The patient may develop neutralizing antibodies reducing the effectiveness of muromonab-CD3. This complex of ciclosporin and cyclophilin inhibits the phosphatase calcineurin, which under normal circumstances induces the transcription of interleukin-2. So when you say, "Babe, I got it from the pool, I swear," you're telling the truth. Zotarolimus is a semi-synthetic derivative of sirolimus used in drug-eluting stents. Imperfections in clinical trials, such as insufficient number of patients or short duration, sometimes lead to public health disasters, such as those of fenfluramine (the so-called fen-phen episode), thalidomide and, more recently, of cerivastatin (Baycol, Lipobay) and rofecoxib (Vioxx), where drastic adverse effects were observed, such as teratogenesis, pulmonary hypertension, stroke, heart disease, neuropathy, and a significant number of deaths, causing the forced or voluntary withdrawal of the drug from the market. Tacrolimus is more potent than ciclosporin and has less pronounced side-effects. Common side effects of methylphenidate include difficulty sleeping, decreased appetite, anxiety, and weight loss. It binds to FKBP1A like tacrolimus, however the complex does not inhibit calcineurin but another protein, mTOR. By preventing the clonal expansion of lymphocytes in the induction phase of the immune response, it affects both the cell and the humoral immunity. All drugs can have potential side effects. Like the original, its side effects are nasty: paranoia, psychological addiction. Drugs sold under the street names ecstasy, molly, or mandy are often advertised as pure MDMA, but are often mixed with multiple other drugs. The meaning of this term differs from the term "side effect" because side effects can be beneficial as well as detrimental.The study of ADRs is the concern of the field known as pharmacovigilance. Within HPFB, the Marketed Health Products Directorate leads the coordination and implementation of consistent monitoring practices with regards to assessment of signals and safety trends, and risk communications concerning regulated marketed health products. It is possible to diminish their toxicity by using highly purified serum fractions and intravenous administration in the combination with other immunosuppressants, for example, calcineurin inhibitors, cytostatics, and corticosteroids. In the first few administrations this binding non-specifically activates T-cells, leading to a serious syndrome 30 to 60 minutes later. Any medication can cause side effects, and high blood pressure (HBP) medications are no exception. Adverse reaction reporting is an important component of New Zealand's pharmacovigilance activities. It increases the expression or changes the function of certain adhesion molecules (α4/β7 integrin) in lymphocytes, so they accumulate in the lymphatic tissue (lymphatic nodes) and their number in the circulation is diminished. CD3 antibodies shift the balance from Th1 to Th2 cells as CD3 stimulates Th1 activation. DISCLAIMER The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. In this respect, it differs from all other known immunosuppressants. Though if you are, in fact, lying, maybe learn the best way to apologize to a woman scorned. Adverse effects are sometimes referred to as "iatrogenic" because they are generated by a physician/treatment. It may also be indicated by symptoms reported by a patient. The Centre for Adverse Reactions Monitoring (CARM) in Dunedin is New Zealand's national monitoring centre for adverse reactions. These drugs may raise the risk of contracting tuberculosis or inducing a latent infection to become active. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, lipodystrophy, moon face, liver and kidney injury. An adverse drug reaction (ADR) is an injury caused by taking medication. TNF or the effects of TNF are also suppressed by various natural compounds, including curcumin (an ingredient in turmeric) and catechins (in green tea). Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry. The results of several studies suggest that calcineurin inhibitors have oncogenic properties mainly linked to the production of cytokines that promote tumor growth, metastasis and angiogenesis. For example, a limb may be lost to amputation in case of untreatable gangrene, but the patient's life is saved. Glucocorticoids suppress the cell-mediated immunity. Drugs and diseases, such as aspirin and peptic ulcers; Interactions can change the actions of one or both drugs. The antilymphocyte (ALG) and antithymocyte antigens (ATG) are being used. Ciclosporin is thought to bind to the cytosolic protein cyclophilin (an immunophilin) of immunocompetent lymphocytes, especially T-lymphocytes. Antimetabolites interfere with the synthesis of nucleic acids. Monoclonal antibodies are directed towards exactly defined antigens. Drug abusers choose drugs over all else; that includes family and friends. Psychological drug abuse effects commonly include changes in mood. An adverse effect may be termed a "side effect", when judged to be secondary to a main or therapeutic effect. Heterologous polyclonal antibodies are obtained from the serum of animals (e.g., rabbit, horse), and injected with the patient's thymocytes or lymphocytes. It is taken by mouth as a tablet or solution and may be used in children over the age of three months. The cross-binding of CD3 molecules as well activates an intracellular signal causing the T cell anergy or apoptosis, unless the cells receive another signal through a co-stimulatory molecule. Interleukin-2 is an important immune system regulator necessary for the clone expansion and survival of activated lymphocytes T. Its effects are mediated by the trimer cell surface receptor IL-2a, consisting of the α, β, and γ chains. Immunosuppressive drugs are used in immunosuppressive therapy to: A common side-effect of many immunosuppressive drugs is immunodeficiency, because the majority of them act non-selectively, resulting in increased susceptibility to infections and decreased cancer immunosurveillance. This is done in toxicity studies to determine the nonadverse effect level (NOAEL). More frequently reported side effects include:fatigue. It is also efficient in the treatment of autoimmune diseases. Calcineurin inhibitors and azathioprine have been linked with post-transplant malignancies and skin cancers in organ transplant recipients. It is characterized by fever, myalgia, headache, and arthralgia. Adverse effects may also be caused by drug interaction. Adverse effects of medical treatment resulted in 142,000 deaths in 2013 up from 94,000 deaths in 1990 globally.[3]. See below for a comprehensive list of adverse effects. One of the side effects of drug abuse is the loss of friendship and family due to these choices. It is used to slow down the progression of multiple sclerosis. For example, extracts of St John's wort (Hypericum perforatum), a phytotherapic used for treating mild depression are known to cause an increase in the cytochrome P450 enzymes responsible for the metabolism and elimination of many drugs, so patients taking it are likely to experience a reduction in blood levels of drugs they are taking for other purposes, such as cancer chemotherapeutic drugs, protease inhibitors for HIV and hormonal contraceptives. Diagnostic procedures may also have adverse effects, depending much on whether they are invasive, minimally invasive or noninvasive. Those who abuse drugs over an extended period are in danger of developing a number of mental and physical health problems. It is used in kidney transplantations. However, some side effects sometimes produce unexpected and potentially beneficial effects or unexpected. Common adverse effects may be fever, malaise and local reactions in the vaccination site. In terms of drugs, adverse events may be defined as: “Any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have to have a causal relationship with this treatment.”[4]. The effects of drug consumption on the brain are divided, based on the drug substance, how it attacks the brain, the immediate or short-term impact and what can occur in the long run. Such effects are generally known as side-effects. Although it is a structural analogue of tacrolimus, it acts somewhat differently and has different side-effects. it is the most frequently used of all the artemesinin-type drugs. In immunotherapy, they are used in smaller doses than in the treatment of malignant diseases. Drugs and The Brain. Patients stay in the hospital as long as three weeks to give the immune system time to recover to a point where there is no longer a risk of serum sickness. Some have described the worst side effects of the drug for patients with heart conditions as “drug-induced cardiac arrests. They are usually administered for five days intravenously in the appropriate quantity. Glucocorticoids influence all types of inflammatory events, no matter their cause. Mercaptopurine itself can also be administered directly. Bad side effects include insomnia, nausea, rapid heartbeat, and addiction. Muromonab-CD3 can cause excessive immunosuppression. As of March 2005, there are two preparations available to the market: Atgam, obtained from horse serum, and Thymoglobuline, obtained from rabbit serum. Adverse effects, like therapeutic effects of drugs, are a function of dosage or drug levels at the target organs, so they may be avoided or decreased by means of careful and precise pharmacokinetics, the change of drug levels in the organism in function of time after administration. ADRAC publishes the Australian Adverse Drug Reactions Bulletin every two months. The harmful effects of drugs on the brain due to prolonged usage are deterioration of the nerves, blood vessels, which may finally affect the brain, as a result of which brain damage occurs, which is an irreversible condition. Side effects of drug abuse then include preoccupation with where to get the drug, how to get money for the drug, and where and when the drug can be used. They induce the lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. These effects, which have a widely variable incidence according to individual sensitivity, include nausea, dizziness, diarrhea, malaise, vomiting, headache, dermatitis, dry mouth, etc. In a similar manner, Sirolimus prevents B cell differentiation into plasma cells, reducing production of IgM, IgG, and IgA antibodies. Prolonged use of opioids may cause immunosuppression of both innate and adaptive immunity. It is nonenzymatically cleaved to mercaptopurine, that acts as a purine analogue and an inhibitor of DNA synthesis. It increases the risk of heart failure, kidney failure, and liver failure. Everolimus is an analog of sirolimus and also is an mTOR inhibitor. They are part of the steroid-resistant acute rejection reaction and grave aplastic anemia treatment. [7], Learn how and when to remove this template message, post-transplant lymphoproliferative disorders, Discovery and development of mTOR inhibitors, Treatment methods for preventing organ rejection, "Marketed therapeutic antibodies compendium", "Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling", "Monoclonal antibodies that identify the CD3 molecules expressed specifically at the surface of porcine γδ-T cells", WSAVA 2001 – Immunosuppressive drug therapy, Principles and Practice of Monitoring Immunosuppressive Drugs. Ofloxacin, the most common of ear infection, or "swimmers ear," drugs, has a strange side effect: It can cause genital itching. Additional side effects can result from interaction with other drugs, such as the possibility of tendon damage from the administration of a quinolone antibiotic with a systemic corticosteroid. Glucocorticoids also stimulate the lipocortin-1 escaping to the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammatory events: epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst, and the release of various inflammatory mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines, etc.) [citation needed] Artesunate is a hemisuccinate derivative of the active metabolite dihydroartemisin. Some adverse effects occur only when starting, increasing or discontinuing a treatment. The law says a person cannot own an controlled drug without permission. Due to their highest effectiveness, purine analogs are most frequently administered. Infliximab and adalimumab have label warnings stating that patients should be evaluated for latent TB infection and treatment should be initiated prior to starting therapy with them. Surgery may have a number of undesirable or harmful effects, such as infection, hemorrhage, inflammation, scarring, loss of function, or changes in local blood flow. They are used in the prophylaxis of the acute organ rejection after bilateral kidney transplantation, both being similarly effective and with only few side-effects. An adverse effect is an undesired harmful effect resulting from a medication or other intervention, such as surgery. This often occurs when patients fail to inform their physician and pharmacist of all the medications they are taking, including herbal and dietary supplements. ADRs may occur following a single dose or prolonged administration of a drug or result from the combination of two or more drugs. In patients with end-stage cancer, death is a very likely outcome and whether the drug is the cause or a bystander is often difficult to discern. Glucocorticoids also suppress the humoral immunity, causing B cells to express smaller amounts of IL-2 and IL-2 receptors. Fingolimod is a new synthetic immunosuppressant, currently in phase 3 of clinical trials. Or problems that occur in addition to the desired therapeutic effect. However, muromonab-CD3 is no longer produced,[1] and this mouse monoclonal antibody has been replaced in the clinic with chimeric, humanized, or human monoclonal antibodies. [8] To balance the overemphasis on benefit, scholars have called for more complete reporting of harm from clinical trials.[9]. In Canada, adverse reaction reporting is an important component of the surveillance of marketed health products conducted by the Health Products and Food Branch (HPFB) of Health Canada. It is extensively used to control transplant rejection reactions. These can be considered a form of pseudo-allergic reaction, as not all users experience these effects; many users experience none at all. The scheme also includes all herbal supplements and unlicensed medicines found in cosmetic treatments. Side effects can vary from minor problems like a … In addition to physical side effects, drug use can also cause mental strain, altering thought processes and therefore behaviors and actions as well. The distinction between adverse and nonadverse effects is a major undertaking when a new drug is developed and tested before marketing it. Side Effects is an anthology of 17 comical short essays written by Woody Allen between 1975 and 1980, all but one of which were previously published in, variously, The New Republic, The New York Times, The New Yorker, and The Kenyon Review.It includes Allen's 1978 O. Henry Award winning story, "The Kugelmass Episode". It is therefore important to take the right amount. This should be taken into consideration in patients who need a sodium-restricted diet. Drugs act differently in different amounts. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. . Long-term use of many drugs can lead to physical drug dependence, major withdrawal symptoms, and addiction. In contrast to other human cell types, lymphocytes B and T are very dependent on this process. Myriocin has been reported being 10 to 100 times more potent than Ciclosporin. No link has been found in several large studies, and despite removal of thimerosal from vaccines a decade ago the rate of autism has not decreased as would be expected if it had been the causative agent. Mit Side Effects hat Steven Soderbergh seine Regie-Karriere vorübergehend beendet. 12. However, they are added primarily to other immunosuppressives to diminish their dosage and toxicity. Side effects: Problems that occur when treatment goes beyond the desired effect. Most biologic drugs have the potential to cause allergic hypersensitivity reactions. They are also administered as posttransplantory immunosuppressants to prevent the acute transplant rejection and graft-versus-host disease. These drugs act by binding the IL-2a receptor's α chain, preventing the IL-2 induced clonal expansion of activated lymphocytes and shortening their survival. Ciclosporin is used in the treatment of acute rejection reactions, but has been increasingly substituted with newer, and less nephrotoxic,[4] immunosuppressants. Research side effects, dosages, interactions and review data. It is reasonable to expect similar new drugs in the future. Therefore, it is of special significance to the selective immunosuppressive treatment, and research has been focused on the development of effective and safe anti-IL-2 antibodies. Sometimes, putative medical adverse effects are regarded as controversial and generate heated discussions in society and lawsuits against drug manufacturers. Proton pump inhibitors may … A headache in a patient taking medication for influenza may be caused by the underlying disease or may be an adverse effect of the treatment. Methylphenidate is believed to work by blocking dopamine and norepinephrine reuptake by neurons. [6] Decrease in proliferation as well as immune function has been observed in macrophages, as well as lymphocytes. IFN-β suppresses the production of Th1 cytokines and the activation of monocytes. [5] The results of trials are often included in the labelling of the medication to provide information both for patients and the prescribing physicians. Drug-drug and food-drug interactions may occur, and so-called "natural drugs" used in alternative medicine can have dangerous adverse effects. Adverse effects may cause a reversible or irreversible change, including an increase or decrease in the susceptibility of the individual to other chemicals, foods, or procedures, such as drug interactions. Adverse effects may cause complications of a disease or procedure and negatively affect its prognosis. Later during the treatment, some patients develop serum sickness or immune complex glomerulonephritis. In this way, polyclonal antibodies inhibit cell-mediated immune reactions, including graft rejection, delayed hypersensitivity (i.e., tuberculin skin reaction), and the graft-versus-host disease (GVHD), but influence thymus-dependent antibody production. They also allow transition to cyclosporin therapy. The term "life-threatening" in the context of a serious adverse event refers to an event in which the patient was at risk of death at the time of the event; it does not refer to an event which hypothetically might have caused death if it were more severe. Its only effect is mediated through a reduction in the gametocyte transmission. ", "Lactic acidosis associated with stavudine administration: a report of five cases", "How do you know if you have rhabdomyolysis from statin use? However, many people have no side effects or only have minor side effects. All drugs may cause side effects. Side effects, also known as adverse events, are unwanted or unexpected events or reactions to a drug. Also, it indirectly inhibits several T lymphocyte-specific kinases and phosphatases, hence preventing their transition from G1 to S phase of the cell cycle. The scientific field of activity associated with drug safety is increasingly government-regulated, and is of major concern for the public, as well as to drug manufacturers. Common, immediate effects of methamphetamine abuse include: Other side effects include temporary hyperactivity, insomnia, anorexia and tremors. [1][2] One example is the recent controversy as to whether autism was linked to the MMR vaccine (or by thiomersal, a mercury-based preservative used in some vaccines). It is a cyclic fungal peptide, composed of 11 amino acids. A TNF-α (tumor necrosis factor-alpha) binding protein is a monoclonal antibody or a circulating receptor such as infliximab (Remicade), etanercept (Enbrel), or adalimumab (Humira) that binds to TNF-α, preventing it from inducing the synthesis of IL-1 and IL-6 and the adhesion of lymphocyte-activating molecules. It is a macrolide lactone and acts by inhibiting calcineurin. Very rarely, there is a serious adverse effect, such as eczema vaccinatum, a severe, sometimes fatal complication which may result in persons who have eczema or atopic dermatitis. Generally, any event which causes death, permanent damage, birth defects, or requires hospitalization is considered a serious adverse event. As it acts more specifically than polyclonal antibodies it was also used prophylactically in transplantations. MHPD also works closely with international organizations to facilitate the sharing of information. Aspirin is often prescribed against fever, or as an analgesic. Contrary to ciclosporin and tacrolimus, drugs that affect the first phase of T lymphocyte activation, sirolimus affects the second phase, namely signal transduction and lymphocyte clonal proliferation. The Government's Quality Use of Medicines program is tasked with acting on this reporting to reduce and minimize the number of preventable adverse effects each year. A person may be anxious, thinking about when they can next use the drug, or depressed due to drug … It is characterized by fever, rigor episodes, and even anaphylaxis. Immunosuppressive drugs, also known as immunosuppressive agents, immunosuppressants and antirejection medications are drugs that inhibit or prevent activity of the immune system. Mycophenolate mofetil is used in combination with ciclosporin or tacrolimus in transplant patients. IFN-γ is able to trigger lymphocytic apoptosis. Vaccination may have adverse effects due to the nature of its biological preparation, sometimes using attenuated pathogens and toxins. Therefore, sirolimus acts synergistically with ciclosporin and, in combination with other immunosuppressants, has few side effects. Commonly reported side effects of ramipril include: hypotension and increased cough. Other important side effects include: Nervousness, abnormal heartbeat, muscle pain, weakness, leg cramps and water retention occur infrequently. Compared to other NSAIDs, it may have other side effects such as gastrointestinal bleeding. The drug is used primarily in liver and kidney transplantations, although in some clinics it is used in heart, lung, and heart/lung transplantations. Due to the exceedingly high impact on public health of widely used medications, such as hormonal contraception and hormone replacement therapy, which may affect millions of users, even marginal probabilities of adverse effects of a severe nature, such as breast cancer, have led to public outcry and changes in medical therapy, although its benefits largely surpassed the statistical risks. Presently, one of the greatest advantages of Because of a high immunogenicity of polyclonal antibodies, almost all patients have an acute reaction to the treatment. National Kidney Foundation: A to Z Health Guide, Immunosuppressants, Pharmacologic profile, Post-transplant lymphoproliferative disorder, List of organ transplant donors and recipients, https://en.wikipedia.org/w/index.php?title=Immunosuppressive_drug&oldid=999979770, Articles needing additional references from June 2009, All articles needing additional references, Creative Commons Attribution-ShareAlike License, Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic, This page was last edited on 12 January 2021, at 22:41. The effects lasts between 2-7 minutes. , has few side effects: problems that occur when treatment goes side effects of drugs wikipedia the desired therapeutic.. To bind to the nature of its biological preparation, sometimes using attenuated pathogens and toxins procedures! 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